Possible Reversion of Pituitary “Thyroidectomy Cells” into their Original Acidophils in Rats

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Possible reversion of pituitary "thyroidectomy cells" into their original acidophils in rats.

Fifteen days after thyroidectomy, the pituitary acidophils of rats were definitely deprived of their large granules , about 350mƒÊ in diameter each, and in due succession, they displayed the changes characterized by the features of "thyroidectomy cells"(TXcells). When these rats were given a single or three injections of thyroxine, 50mg/rat, most of TX-cells might revert to their original acido...

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Fine structure of pituitary acidophils in thyroidectomized rats with or without the treatment with thyroxine and dexamethasone.

Electron microscopic study was made on rat anterior pituitaries in an attempt to clarify the causal mechanism of "loss of acidophils" which could be detected with the light microscope following thyroidectomy. In the advancing days after thyroidectomy, the acidophils (somatotrophs) were gradually deprived of their large granules whose diameter was about 350 mu. There was evidence in vivo for the...

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ژورنال

عنوان ژورنال: Endocrinologia Japonica

سال: 1973

ISSN: 0013-7219,2185-6370

DOI: 10.1507/endocrj1954.20.249